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論文中文名稱:育齡婦女髮甲基汞濃度與魚類攝取之關係及風險評估 [以論文名稱查詢館藏系統]
論文英文名稱:Risk assessment and correlation between hair methylmercury levels and fish consumption for women of childbearing age [以論文名稱查詢館藏系統]
英文姓名:You-Wen Hsu
指導教授英文名:Tien-Chin Chang
口試委員英文名:Hsing-Cheng Hsi
英文關鍵詞:MethylmercuryHairChildbearing ageCommercial fishDaily exposureInfertility
論文中文摘要:本研究主要目的為分析育齡婦女之頭髮甲基汞濃度及臺灣市售魚體之甲基汞濃度,以評估育齡婦女每日由魚體暴露甲基汞之風險。本研究於2007年至2009年分別收集懷孕及不孕婦女之頭髮樣本,其中有七成的婦女頭髮甲基汞超出美國環保署之建議值1 mg kg-1,而不孕婦女幾何平均濃度為1.82±0.14 mg kg-1,懷孕婦女為1.23±0.18 mg kg-1,不孕組顯著高於懷孕組。本研究於2014年採集魚體樣本,濃度範圍為0.001-0.54 mg kg-1。每日甲基汞暴露量中有八成以上的婦女超出美國環保署之建議值0.1 μg kg BW-1 d-1,不孕組的平均顯著高於懷孕組,平均值分別為0.51±0.49及0.34±0.34 μg kg BW-1 d-1。本研究於頭髮甲基汞濃度及每日甲基汞暴露量中皆發現,兩者與懷孕情形間呈顯著正相關,且頭髮甲基汞濃度也與每日甲基汞暴露量呈顯著正相關。由此結果顯示,人體內之汞以及攝入之汞皆可能造成婦女不孕之因子,而當汞攝入量越高體內之汞含量也可能會相對增加。
論文英文摘要:The purposes of this study were to assess the methylmercury (MeHg) concentrations in hair of women of childbearing age and in commercial fish in Taiwan, and to calculate the daily exposure of MeHg to evaluate the risk of fish consumption for these women. This study collected hair samples from infertile and pregnant women between years 2007 and 2009, and analyzed the MeHg concentration in hair. Nearly 70% of women of childbearing age had hair MeHg concentration equal to or greater than 1 mg kg-1, the USEPA reference dose. The geometric means of women’s hair MeHg were 1.82±0.14 mg kg-1 and 1.23±0.18 mg kg-1 for the infertile and pregnant women, respectively. The hair MeHg concentration in infertile women was significantly greater than that in pregnant women (p<0.05).
This study further collected fish samples in 2014, and analyzed their MeHg concentration in fish.The Concentration of MeHg in fishes ranged from 0.001 to 0.54 mg kg-1. Results indicated that over 80% of women of childbearing age had estimated daily MeHg dose exceeding the reference dose, i.e., 0.1 μg kg BW-1 d-1. The averaged women’s daily MeHg exposure dose were 0.51±0.49 and 0.34±0.34 μg kg BW-1d-1 for the infertile and pregnant women, respectively. The daily MeHg exposure dose in infertile groups was significantly larger than that in pregnant women (p<0.01). Pregnancy is significantly correlated with hair MeHg and daily MeHg exposure doses (p<0.05 and p<0.01, respectively), and a significantly correlation between hair MeHg concentrations and daily MeHg exposure was observed (p<0.01). This result shows that the intake of mercury and mercury in the body may cause women infertility.
論文目次:摘 要 ii
誌 謝 v
目錄 vi
表目錄 viii
圖目錄 ix
第一章 前言 1
1.1 研究緣起 1
1.2 研究目的 3
第二章 文獻回顧 4
2.1 汞之特性 4
2.1.1 汞的型態 4
2.1.2 汞的環境流布 5
2.1.3 汞循環 7
2.1.4 汞之暴露途徑及健康危害 8
2.2 魚體及人體中的汞 10
2.2.1 魚體內之汞 10
2.2.2 臺灣魚類消費及汞含量情形 12
2.2.3 甲基汞進入人體之機制 14
2.2.4 人體內之甲基汞 15
2.2.5 汞的容許濃度建議值 21
2.3 婦女汞暴露之相關研究 24
2.3.1 婦女汞暴露與懷孕之相關研究 24
2.3.2 婦女汞暴露與魚類攝取之相關研究 25
2.3.3 婦女魚體汞暴露認知之相關研究 26
2.4 生物檢體選擇 26
2.5 暴露評估 28
第三章 材料與方法 30
3.1 研究架構 30
3.2 研究設計與流程 31
3.3 樣本及資料收集 32
3.3.1 問卷訪視 32
3.3.2 頭髮樣本收集 32
3.3.3 魚體樣本收集 32
3.4 樣本甲基汞分析 33
3.4.1 試劑與儀器設備 33
3.4.2 樣品前處理 35
3.4.3 品質管制 36
3.5 甲基汞暴露評估 38
3.6 資料分析方法 39
第四章 結果與討論 40
4.1 研究個案基本人口學特徵與生活飲食習慣 40
4.2 魚體甲基汞濃度 45
4.3 婦女頭髮中甲基汞濃度 51
4.4 婦女頭髮甲基汞濃度高低與相關因子分析 59
4.5 甲基汞濃度與懷孕情形之二因子相關性 62
4.5.1. 研究限制 62
4.6 婦女每日甲基汞暴露劑量 63
4.7 每日甲基汞暴露量與頭髮甲基汞之關係 70
4.8 甲基汞濃度與魚類含汞認知差異之關係 72
第五章 結論與建議 74
結論 74
建議 75
參考文獻 76
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楊子萱,兒童在胎兒及幼兒時期汞、甲基汞暴露 對其三歲時認知、語言、動作發展之影響,碩士論文,臺北醫學大學公共衛生學系,台北市,2012。
環檢所,NIEA W540.50B,「水中甲基汞檢測方法-蒸餾/液相乙基化/吹氣捕捉/冷蒸氣原子螢光光譜法」,2009。