現在位置首頁 > 博碩士論文 > 詳目
  • 同意授權
論文中文名稱:生物醫學上的奈米粒子研究回顧 [以論文名稱查詢館藏系統]
論文英文名稱:Review:nanoparticle researches in biomedicine [以論文名稱查詢館藏系統]
英文姓名:Yen-Ting Chen
英文關鍵詞:gold nanoparticlemagnetic nanoparticledetectiondiagnosis
論文中文摘要:奈米科學的發展對各種科學領域造成強烈的衝擊,使得各種不同的技術不斷被開發。在生物醫學方面,由於奈米粒子特殊的物理化學性質及生物相容性在偵測及診斷上成為常使用的平台。金奈米粒子可以和蛋白質(通常是抗體)以物理吸附或與經過硫醇修飾的核酸序列形成硫金共價鍵使其成為偵測探針。另外由於其特殊的光學特性(surface-enhanced Raman、Rayleigh scattering及aggregation dependent shifts in plasmon frequency)在生物醫學的診斷方面有很大的應用。奈米磁珠上也可以修飾抗體等蛋白質,利用抗原和抗體間的結合來捕捉特定蛋白。其最大特點在於能夠利用磁場使其純化蛋白。
在本篇文章中,主要著重在近幾年金奈米粒子(gold nanoparticle、nanorod及nanoshell)、奈米磁珠(magnetic nanoparticle)及其他奈米粒子用於生物醫學上的偵測、診斷及特殊應用。
論文英文摘要:Advances in nanoscience have a significant impact on many scientific fields, boosting the development of a variety of important technologies. Because nanoparticles have special physicochemical properties and the biological compatibility, it become an important platform in the detection and the diagnosis. Gold nanoparticles bind with the proteins, such as antibodies, using physisorption or the sulfur-gold covalent bond to become the target-specific probe. In addition, because its special optics characteristic(surface-enhanced Raman、Rayleigh scattering and aggregation dependent shifts in plasmon frequency),these are many applications in the biomedicine diagnosis aspect. The magnetic nanoparticle modified with antibody catches the specific protein using interaction force between the antigen and antibody. In this review, we examine recent advances in gold nanoparticles, magnetic nanoparticles and their application in biomedicine detection, diagnosis and other special applications.
論文目次:中文摘要 i
英文摘要 ii
誌謝 iii
目錄 iv
表目錄 vi
圖目錄 vii
第一章 緒論 1
1.1 簡介奈米材料 1
1.2 生物醫學上的奈米粒子 3
1.2.1 碳簇分子 5
1.2.2 量子點 6
1.2.3 銀奈米粒子 7
第二章 金奈米粒子 9
2.1 金奈米粒子的特性 9
2.1.1 光學特性 9
2.1.2 表面修飾 12
2.2 金奈米粒子的研究 13
2.2.1 核酸檢測方法 14 SNP的檢測 14 核酸增加量的偵測 18 利用Aptamers的偵測 19 生物條碼系統 21
第三章 磁性奈米粒子 23
3.1 磁性奈米粒子的特性 23
3.2 磁性奈米粒子的包覆修飾 25
3.2.1 高分子包覆磁性奈米粒子 25
3.2.2 以liposomes/micelles形式包覆磁性奈米粒子 27
3.3 磁性奈米粒子的研究 28
3.2.1 磁性免疫分析 28
3.2.1 磁性分離 29
3.2.1 磁性奈米粒子與MRI影像增強 31
3.2.1 磁熱效應 33
第四章 多功能奈米粒子 34
4.1 金/磁性奈米粒子 34
4.1.1 包覆金殼的磁性奈米粒子 34
4.1.2 啞鈴型的金磁奈米粒子 36
參考文獻 39
A金/鈀奈米粒子的原子數與表面原子比例關係計算方式 51
B本篇論文引用review paper 整理表 52
論文參考文獻:1.Hurst, S.J., Hill, H.D., Mirkin, C.A. “"Three-dimensional hybridization" with polyvalent DNA-gold nanoparticle conjugates” (2008) Journal of the American Chemical Society, 130 (36), pp. 12192-12200
2.Han, M., Gao, X., Su, J.Z., Nie, S. “Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules” (2001) Nature Biotechnology, 19 (7), pp. 631-635.
3.Gu, H., Xu, K., Xu, C., Xu, B. “Biofunctional magnetic nanoparticles for protein separation and pathogen detection” (2006) Chemical Communications, (9), pp. 941-949.
4.Suh, W.H., Suslick, K.S., Stucky, G.D., Suh, Y.-H.“Nanotechnology, nanotoxicology, and neuroscience” (2009) Progress in Neurobiology, 87 (3), pp. 133-170.
5.Innocenzi, P., Brusatin, G. “Fullerene-based organic-inorganic nanocomposites and their applications” (2001) Chemistry of Materials, 13 (10), pp. 3126-3139.
6.Li, Y., Wang, S., Li, F., Du, C., Shi, Z., Zhu, D., Song, Y. “Preparation and optical limiting properties of polycarbonates containing fullerene unit” (2001) Chemical Physics Letters, 337 (4-6), pp. 403-407.
7.Park, J.H., Choi, D.G., Lee, T.K., Oh, E., Lee, S., Furdyna, J.K. “Localization and interdot carrier transfer in CdSe and CdZnMnSe quantum dots determined by cw and time-resolved photoluminescence” (2007) Applied Physics Letters, 90 (20), art. no. 201916, .
8.Shen, Q., Kobayashi, J., Diguna, L.J., Toyoda, T. “Effect of ZnS coating on the photovoltaic properties of CdSe quantum dot-sensitized solar cells” (2008) Journal of Applied Physics, 103 (8), art. no. 084304, .
9.Green, M., O'Brien, P. “Recent advances in the preparation of semiconductors as isolated nanometric particles: New routes to quantum dots” (1999) Chemical Communications, (22), pp. 2235-2241.
10.Feng, Q.L., Cui, F.Z., Kim, T.N., Kim, J.W. “Ag-substituted hydroxyapatite coatings with both antimicrobial effects and biocompatibility” (1999) Journal of Materials Science Letters, 18 (7), pp. 559-561.
11.Fritzsche, W., Porwol, H., Wiegand, A., Bornmann, S., Ko?hler, J.M. “In-situ formation of Ag-containing nanoparticles in thin polymer films” (1998) Nanostructured Materials, 10 (1), pp. 89-97.
12.Shiraishi, Y., Toshima, N. “Oxidation of ethylene catalyzed by colloidal dispersions of poly(sodium acrylate)-protected silver nanoclusters” (2000) Colloids and Surfaces A: Physicochemical and Engineering Aspects, 169 (1-3), pp. 59-66.
13.Nam, J.-M., Thaxton, C.S., Mirkin, C.A. “Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins” (2003) Science, 301 (5641), pp. 1884-1886.
14.Nie, S., Emory, S.R. “Probing single molecules and single nanoparticles by surface-enhanced Raman scattering” (1997) Science, 275 (5303), pp. 1102-1106.
15.Seitz, O., Chehimi, M.M., Cabet-Deliry, E., Truong, S., Felidj, N., Perruchot, C., Greaves, S.J., Watts, J.F. “Preparation and characterisation of gold nanoparticle assemblies on silanised glass plates” (2003) Colloids and Surfaces A: Physicochemical and Engineering Aspects, 218 (1-3), pp. 225-239.
16.Michael Faraday “The Bakerian Lecture: Experimental Relations of Gold (and Other Metals) to Light” (1857) Philosophical Transactions of the Royal Society of London, Vol. 147, pp. 145-181
17.Katz, E., Willner, I. “Integrated nanoparticle-biomolecule hybrid systems: Synthesis, properties, and applications” (2004) Angewandte Chemie - International Edition, 43 (45), pp. 6042-6108.
18.Sokolova, V., Epple, M. “Inorganic nanoparticles as carriers of nucleic acids into cells” (2008) Angewandte Chemie - International Edition, 47 (8), pp. 1382-1395.
19.Ghadiali, J.E., Stevens, M.M. “Enzyme-responsive nanoparticle systems” (2008) Advanced Materials, 20 (22), pp. 4359-4363.
20. Myroshnychenko, V., Rodriguez-Fernandez, J., Pastoriza-Santos, I., Funston, A.M., Novo, C., Mulvaney, P., Liz-Marzan, L.M., Garcia De Abajo, F.J. “Modelling the optical response of gold nanoparticles” (2008) Chemical Society Reviews, 37 (9), pp. 1792-1805.21. Stewart, M.E., Anderton, C.R., Thompson, L.B., Maria, J., Gray, S.K., Rogers, J.A., Nuzzo, R.G. “Nanostructured plasmonic sensors” (2008) Chemical Reviews, 108 (2), pp. 494-521.
22. Murphy, C.J., Gole, A.M., Stone, J.W., Sisco, P.N., Alkilany, A.M., Goldsmith, E.C., Baxter, S.C. “Gold nanoparticles in biology: Beyond toxicity to cellular imaging” (2008) Accounts of Chemical Research, 41 (12), pp. 1721-1730.
23. Rosi, N.L., Mirkin, C.A. “Nanostructures in biodiagnostics” (2005) Chemical Reviews, 105 (4), pp. 1547-1562.
24. You, C.-C., De, M., Rotello, V.M. “Monolayer-protected nanoparticle-protein interactions” (2005) Current Opinion in Chemical Biology, 9 (6), pp. 639-646.
25. Niemeyer, C.M. “Nanoparticles, proteins, and nucleic acids: Biotechnology meets materials science” (2001) Angewandte Chemie - International Edition, 40 (22), pp. 4129-4158.
26. Daniel, M.-C., Astruc, D. “Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications Toward Biology, Catalysis, and Nanotechnology” (2004) Chemical Reviews, 104 (1), pp. 293-346.
27. Shenton, W., Davis, S.A., Mann, S. “Directed self-assembly of nanoparticles into macroscopic materials using antibody-antigen recognition” (1999) Advanced Materials, 11 (6), pp. 449-452.
28. Wang, Z., Ma, L.“Gold nanoparticle probes”(2009) Coordination Chemistry Reviews, 253 (11-12), pp. 1607-1618.
29. Azzazy, H.M.E., Mansour, M.M.H., Kazmierczak, S.C. “Nanodiagnostics: A new frontier for clinical laboratory medicine” (2006) Clinical Chemistry, 52 (7), pp. 1238-1246.
30. Fortina, P., Kricka, L.J., Surrey, S., Grodzinski, P. “Nanobiotechnology: The promise and reality of new approaches to molecular recognition” (2005) Trends in Biotechnology, 23 (4), pp. 168-173.
31. Wilson, R. “The use of gold nanoparticles in diagnostics and detection” (2008) Chemical Society Reviews, 37 (9), pp. 2028-2045.
32. Jain, K.K. “Applications of nanobiotechnology in clinical diagnostics” (2007) Clinical Chemistry, 53 (11), pp. 2002-2009.
33. Mirkin, C.A., Letsinger, R.L., Mucic, R.C., Storhoff, J.J. “A DNA-based method for rationally assembling nanoparticles into macroscopic materials” (1996) Nature, 382 (6592), pp. 607-609.
34. Elghanian, R., Storhoff, J.J., Mucic, R.C., Letsinger, R.L., Mirkin, C.A. “Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles” (1997) Science, 277 (5329), pp. 1078-1081.
35. Shenhar, R., Rotello, V.M. “Nanoparticles: Scaffolds and building blocks” (2003) Accounts of Chemical Research, 36 (7), pp. 549-561.
36. Murphy, C.J. “Materials science: Nanocubes and nanoboxes” (2002) Science, 298 (5601), pp. 2139-2141.
37. Wabuyele, M.B., Farquar, H., Stryjewski, W., Hammer, R.P., Soper, S.A., Cheng, Y.-W., Barany, F. “Approaching real-time molecular diagnostics: Single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes” (2003) Journal of the American Chemical Society, 125 (23), pp. 6937-6945.
38. Wu, D.Y., Ugozzoli, L., Pal, B.K., Wallace, R.B. “Allele-specific enzymatic amplification of β-globin genomic DNA for diagnosis of sickle cell anemia” (1989) Proceedings of the National Academy of Sciences of the United States of America, 86 (8), pp. 2757-2760.
39. Thaxton, C.S., Georganopoulou, D.G., Mirkin, C.A. “Gold nanoparticle probes for the detection of nucleic acid targets” (2006) Clinica Chimica Acta, 363 (1-2), pp. 120-126.
40. Li, J., Chu, X., Liu, Y., Jiang, J.H., He, Z., Zhang, Z., Shen, G., Yu, R.Q. “A colorimetric method for point mutation detection using high-fidelity DNA ligase.” (2005) Nucleic acids research, 33 (19), .
41. Sato, K., Hosokawa, K., Maeda, M. “Rapid aggregation of gold nanoparticles induced by non-cross-linking DNA hybridization” (2003) Journal of the American Chemical Society, 125 (27), pp. 8102-8103.
42. Herdt, A.R., Drawz, S.M., Kang, Y., Taton, T.A. “DNA dissociation and degradation at gold nanoparticle surfaces” (2006) Colloids and Surfaces B: Biointerfaces, 51 (2), pp. 130-139.
43. Tan, E., Wong, J., Nguyen, D., Zhang, Y., Erwin, B., Van Ness, L.K., Baker, S.M., Galas, D.J., Niemz, A. “Isothermal DNA amplification coupled with DNA nanosphere-based colorimetric detection” (2005) Analytical Chemistry, 77 (24), pp. 7984-7992.
44. Tan, E., Erwin, B., Dames, S., Voelkerding, K., Niemz, A. “Isothermal DNA amplification with gold nanosphere-based visual colorimetric readout for herpes simplex virus detection” (2007) Clinical Chemistry, 53 (11), pp. 2017-2020.
45. Pavlov, V., Xiao, Y., Shlyahovsky, B., Willner, I. “Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin” (2004) Journal of the American Chemical Society, 126 (38), pp. 11768-11769.
46. Huang, C.-C., Huang, Y.-F., Cao, Z., Tan, W., Chang, H.-T. “Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors” (2005) Analytical Chemistry, 77 (17), pp. 5735-5741.
47. Liu, J., Lu, Y. “Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles” (2005) Angewandte Chemie - International Edition, 45 (1), pp. 90-94.
48. Nam, J.-M., Stoeva, S.I., Mirkin, C.A. “Bio-Bar-Code-Based DNA Detection with PCR-like Sensitivity” (2004) Journal of the American Chemical Society, 126 (19), pp. 5932-5933.
49. Hill, H.D., Vega, R.A., Mirkin, C.A. “Nonenzymatic detection of bacterial genomic DNA using the bio bar code assay” (2007) Analytical Chemistry, 79 (23), pp. 9218-9223.
50. Paleček, E., Fojta, M. “Magnetic beads as versatile tools for electrochemical DNA and protein biosensing” (2007) Talanta, 74 (3), pp. 276-290.
51. Gupta, A.K., Gupta, M. “Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications” (2005) Biomaterials, 26 (18), pp. 3995-4021.
52. Berry, C.C., Curtis, A.S.G. “Functionalisation of magnetic nanoparticles for applications in biomedicine” (2003) Journal of Physics D: Applied Physics, 36 (13), pp. R198-R206.
53. Kohler, N., Fryxell, G.E., Zhang, M. “A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents” (2004) Journal of the American Chemical Society, 126 (23), pp. 7206-7211.
54. Wunderbaldinger, P., Josephson, L., Weissleder, R. “Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles” (2002) Bioconjugate Chemistry, 13 (2), pp. 264-268.
55. Sun, C., Lee, J.S.H., Zhang, M. “Magnetic nanoparticles in MR imaging and drug delivery” (2008) Advanced Drug Delivery Reviews, 60 (11), pp. 1252-1265.
56. Martina, M.-S., Fortin, J.-P., Ménager, C., Clément, O., Barratt, G., Grabielle-Madelmont, C., Gazeau, F., Cabuil, V., Lesieur, S. “Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging” (2005) Journal of the American Chemical Society, 127 (30), pp. 10676-10685.
57. Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J.S., Chin, S.-F., Sherry, A.D., Boothman, D.A., Gao, J. “Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems” (2006) Nano Letters, 6 (11), pp. 2427-2430.
58. Lecommandoux, S., Sandre, O., Checot, F., Perzynski, R. “Smart hybrid magnetic self-assembled micelles and hollow capsules” (2006) Progress in Solid State Chemistry, 34 (2-4), pp. 171-179.
59. Bauer, J. “Advances in cell separation: Recent developments in counterflow centrifugal elutriation and continuous flow cell separation” (1999) Journal of Chromatography B: Biomedical Sciences and Applications, 722 (1-2), pp. 55-69.
60. Fisher, P.J., Springett, M.J., Dietz, A.B., Bulur, P.A., Vuk-Pavlović, S. “Immunomagnetic separation reagents as markers in electron microscopy” (2002) Journal of Immunological Methods, 262 (1-2), pp. 95-101.
61. Kötitz, R., Weitschies, W., Trahms, L., Brewer, W., Semmler, W. “Determination of the binding reaction between avidin and biotin by relaxation measurements of magnetic nanoparticles” (1999) Journal of Magnetism and Magnetic Materials, 194 (1), pp. 62-68.
62. Jiang, W., Yang, H.C., Yang, S.Y., Horng, H.E., Hung, J.C., Chen, Y.C., Hong, C.-Y. “Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible” (2004) Journal of Magnetism and Magnetic Materials, 283 (2-3), pp. 210-214.
63. Horng, H.E., Yang, S.Y., Huang, Y.W., Jiang, W.Q., Hong, C.-Y., Yang, H.C. “Nanomagnetic particles for SQUID-based magnetically labeled immunoassay” (2005) IEEE Transactions on Applied Superconductivity, 15 (2 PART I), pp. 668-671.
64. Nikitin, P.I., Vetoshko, P.M., Ksenevich, T.I. “New type of biosensor based on magnetic nanoparticle detection” (2007) Journal of Magnetism and Magnetic Materials, 311 (1 SPEC. ISS.), pp. 445-449.
65. Kim, K.S., Park, J.-K. “Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel” (2005) Lab on a Chip - Miniaturisation for Chemistry and Biology, 5 (6), pp. 657-664.
66. Horák, D., Rittich, B., Španová, A., Beneš, M.J. “Magnetic microparticulate carriers with immobilized selective ligands in DNA diagnostics” (2005) Polymer, 46 (4 SPEC. ISS.), pp. 1245-1255.
67. Hourfar, M.K., Michelsen, U., Schmidt, M., Berger, A., Seifried, E., Roth, W.K. “High-throughput purification of viral RNA based on novel aqueous chemistry for nucleic acid isolation” (2005) Clinical Chemistry, 51 (7), pp. 1217-1222.
68. Hourfar, M.K., Schmidt, M., Seifried, E., Roth, W.K. “Evaluation of an automated high-volume extraction method for viral nucleic acids in comparison to a manual procedure with preceding enrichment” (2005) Vox Sanguinis, 89 (2), pp. 71-76.
69. Pichl, L., Heitmann, A., Herzog, P., Oster, J., Smets, H., Schottstedt, V. “Magnetic bead technology in viral RNA and DNA extraction from plasma minipools” (2005) Transfusion, 45 (7), pp. 1106-1110.
70. Rutjes, S.A., Italiaander, R., Van Den Berg, H.H.J.L., Lodder, W.J., De Roda Husman, A.M. “Isolation and detection of enterovirus RNA from large-volume water samples by using the nucliSens miniMAG system and real-time nucleic acid sequence-based amplification” (2005) Applied and Environmental Microbiology, 71 (7), pp. 3734-3740.
71. Lee, C.S., Lee, H., Westervelt, R.M. “Microelectromagnets for the control of magnetic nanoparticles” (2001) Applied Physics Letters, 79 (20), pp. 3308-3310.
72. Gijs, M.A.M. “Magnetic bead handling on-chip: New opportunities for analytical applications” (2004) Microfluidics and Nanofluidics, 1 (1), pp. 22-40.
73. Centi, S., Tombelli, S., Minunni, M., Mascini, M. “Aptamer-based detection of plasma proteins by an electrochemical assay coupled to magnetic beads” (2007) Analytical Chemistry, 79 (4), pp. 1466-1473.
74. Wang, J., Liu, G., Merkoçi, A. “Electrochemical coding technology for simultaneous detection of multiple DNA targets” (2003) Journal of the American Chemical Society, 125 (11), pp. 3214-3215.
75. Wang, J., Liu, G., Jan, M.R. “Ultrasensitive Electrical Biosensing of Proteins and DNA: Carbon-Nanotube Derived Amplification of the Recognition and Transduction Events” (2004) Journal of the American Chemical Society, 126 (10), pp. 3010-3011.
76. Harisinghani, M.G., Weissleder, R. “Sensitive, noninvasive detection of lymph node metastases” (2004) PLoS Medicine, 1, pp. 202-209.
77. Corot, C., Robert, P., Idée, J.-M., Port, M. “Recent advances in iron oxide nanocrystal technology for medical imaging” (2006) Advanced Drug Delivery Reviews, 58 (14), pp. 1471-1504.
78. Semelka, R.C., Helmberger, T.K.G. “State of the art: Contrast agents for mr imaging of the liver” (2001) Radiology, 218 (1), pp. 27-38.
79. Harisinghani, M.G., Barentsz, J., Hahn, P.F., Deserno, W.M., Tabatabaei, S., Van de Kaa, C.H., De la Rosette, J., Weissleder, R. “Noninvasive detection of clinically occult lymph-node metastases in prostate cancer” (2003) New England Journal of Medicine, 348 (25), pp. 2491-2499.
80. Koo, Y.-E.L., Reddy, G.R., Bhojani, M., Schneider, R., Philbert, M.A., Rehemtulla, A., Ross, B.D., Kopelman, R. “Brain cancer diagnosis and therapy with nanoplatforms” (2006) Advanced Drug Delivery Reviews, 58 (14), pp. 1556-1577.
81. Sun, C., Veiseh, O., Gunn, J., Fang, C., Hansen, S., Lee, D., Sze, R., Ellenbogen, R.G., Olson, J., Zhang, M. “In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes” (2008) Small, 4 (3), pp. 372-379.
82. Nielsen, O.S, Horsman, M., Overgaard, J. “A future for hyperthermia in cancer treatment?” (2001) European Journal of Cancer, 37 (13), pp. 1587-1589.
83. Ito, A., Tanaka, K., Honda, H., Abe, S., Yamaguchi, H., Kobayashi, T. “Complete Regression of Mouse Mammary Carcinoma with a Size Greater than 15 mm by Frequent Repeated Hyperthermia Using Magnetite Nanoparticles” (2003) Journal of Bioscience and Bioengineering, 96 (4), pp. 364-369.
84. Cui, Y., Hu, D., Fang, Y., Ma, J. “Preparation and mechanism of Fe3O4/Au core/shell super-paramagnetic microspheres” (2001) Science in China, Series B: Chemistry, 44 (4), pp. 404-410.
85. Cui, Y., Hui, W., Su, J., Wang, Y., Chen, C. “Fe3O4/Au composite nano-particles and their optical properties” (2005) Science in China, Series B: Chemistry, 48 (4), pp. 273-278.
86. Xi, D., Luo, X., Lu, Q., Yao, K., Liu, Z., Ning, Q. “The detection of HBV DNA with gold-coated iron oxide nanoparticle gene probes” (2008) Journal of Nanoparticle Research, 10 (3), pp. 393-400.
87. Cui, Y., Zhang, L., Su, J., Zhang, C., Li, Q., Cui, T., Jin, B., Chen, C. “Synthesis of GoldMag particles with assembled structure and their applications in immunoassay” (2006) Science in China, Series B: Chemistry, 49 (6), pp. 534-540.
88. Cui, Y., Wang, Y., Hui, W., Zhang, Z., Xin, X., Chen, C. “The synthesis of GoldMag nano-particles and their application for antibody immobilization” (2005) Biomedical Microdevices, 7 (2), pp. 153-156.
89. Yu, H., Chen, M., Rice, P.M., Wang, S.X., White, R.L., Sun, S. “Dumbbell-like bifunctional Au-Fe3O4 nanoparticles” (2005) Nano Letters, 5 (2), pp. 379-382.
90. Choi, J.-S., Jun, Y.-W., Yeon, S.-I., Kim, H.C., Shin, J.-S., Cheon, J. “Biocompatible heterostructured nanoparticles for multimodal biological detection” (2006) Journal of the American Chemical Society, 128 (50), pp. 15982-15983.