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論文中文名稱:生物醫學上的奈米粒子研究回顧 [以論文名稱查詢館藏系統]
論文英文名稱:Review:nanoparticle researches in biomedicine [以論文名稱查詢館藏系統]
院校名稱:臺北科技大學
學院名稱:工程學院
系所名稱:生物科技研究所
畢業學年度:97
出版年度:98
中文姓名:陳彥廷
英文姓名:Yen-Ting Chen
研究生學號:95688017
學位類別:碩士
語文別:中文
口試日期:2009-07-24
論文頁數:54
指導教授中文名:侯劭毅
口試委員中文名:黃榮堂;王勝仕
中文關鍵詞:金奈米粒子奈米磁珠偵測診斷
英文關鍵詞:gold nanoparticlemagnetic nanoparticledetectiondiagnosis
論文中文摘要:奈米科學的發展對各種科學領域造成強烈的衝擊,使得各種不同的技術不斷被開發。在生物醫學方面,由於奈米粒子特殊的物理化學性質及生物相容性在偵測及診斷上成為常使用的平台。金奈米粒子可以和蛋白質(通常是抗體)以物理吸附或與經過硫醇修飾的核酸序列形成硫金共價鍵使其成為偵測探針。另外由於其特殊的光學特性(surface-enhanced Raman、Rayleigh scattering及aggregation dependent shifts in plasmon frequency)在生物醫學的診斷方面有很大的應用。奈米磁珠上也可以修飾抗體等蛋白質,利用抗原和抗體間的結合來捕捉特定蛋白。其最大特點在於能夠利用磁場使其純化蛋白。
在本篇文章中,主要著重在近幾年金奈米粒子(gold nanoparticle、nanorod及nanoshell)、奈米磁珠(magnetic nanoparticle)及其他奈米粒子用於生物醫學上的偵測、診斷及特殊應用。
論文英文摘要:Advances in nanoscience have a significant impact on many scientific fields, boosting the development of a variety of important technologies. Because nanoparticles have special physicochemical properties and the biological compatibility, it become an important platform in the detection and the diagnosis. Gold nanoparticles bind with the proteins, such as antibodies, using physisorption or the sulfur-gold covalent bond to become the target-specific probe. In addition, because its special optics characteristic(surface-enhanced Raman、Rayleigh scattering and aggregation dependent shifts in plasmon frequency),these are many applications in the biomedicine diagnosis aspect. The magnetic nanoparticle modified with antibody catches the specific protein using interaction force between the antigen and antibody. In this review, we examine recent advances in gold nanoparticles, magnetic nanoparticles and their application in biomedicine detection, diagnosis and other special applications.
論文目次:中文摘要 i
英文摘要 ii
誌謝 iii
目錄 iv
表目錄 vi
圖目錄 vii
第一章 緒論 1
1.1 簡介奈米材料 1
1.2 生物醫學上的奈米粒子 3
1.2.1 碳簇分子 5
1.2.2 量子點 6
1.2.3 銀奈米粒子 7
第二章 金奈米粒子 9
2.1 金奈米粒子的特性 9
2.1.1 光學特性 9
2.1.2 表面修飾 12
2.2 金奈米粒子的研究 13
2.2.1 核酸檢測方法 14
2.2.1.1 SNP的檢測 14
2.2.1.2 核酸增加量的偵測 18
2.2.1.3 利用Aptamers的偵測 19
2.2.1.4 生物條碼系統 21
第三章 磁性奈米粒子 23
3.1 磁性奈米粒子的特性 23
3.2 磁性奈米粒子的包覆修飾 25
3.2.1 高分子包覆磁性奈米粒子 25
3.2.2 以liposomes/micelles形式包覆磁性奈米粒子 27
3.3 磁性奈米粒子的研究 28
3.2.1 磁性免疫分析 28
3.2.1 磁性分離 29
3.2.1 磁性奈米粒子與MRI影像增強 31
3.2.1 磁熱效應 33
第四章 多功能奈米粒子 34
4.1 金/磁性奈米粒子 34
4.1.1 包覆金殼的磁性奈米粒子 34
4.1.2 啞鈴型的金磁奈米粒子 36
參考文獻 39
附錄
A金/鈀奈米粒子的原子數與表面原子比例關係計算方式 51
B本篇論文引用review paper 整理表 52
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論文全文使用權限:同意授權於2009-08-21起公開